Multi Dynamic Extraction: An Innovative Method to Obtain a Standardized Chemically and Biologically Reproducible Polyphenol Extract from Poplar-Type Propolis to Be Used for Its Anti-Infective Properties.
Identifieur interne : 000831 ( Main/Exploration ); précédent : 000830; suivant : 000832Multi Dynamic Extraction: An Innovative Method to Obtain a Standardized Chemically and Biologically Reproducible Polyphenol Extract from Poplar-Type Propolis to Be Used for Its Anti-Infective Properties.
Auteurs : Vincenzo Zaccaria [Italie] ; Emanuele Ugo Garzarella [Italie] ; Carmen Di Giovanni [Italie] ; Fabio Galeotti [Italie] ; Lucia Gisone [Italie] ; Davide Campoccia [Italie] ; Nicola Volpi [Italie] ; Carla Renata Arciola [Italie] ; Maria Daglia [Italie, République populaire de Chine]Source :
- Materials (Basel, Switzerland) [ 1996-1944 ] ; 2019.
Abstract
Antimicrobial activity is a well-known property of propolis, making it a candidate for antimicrobial surfaces in biomedical devices. Nevertheless, large-scale use of propolis as an anti-infective agent is limited by the heterogeneity of its chemical composition and consequent variation in antimicrobial activity. The aim of this study was to demonstrate that the multi dynamic extraction (M.E.D.) method produces standardized polyphenolic mixtures from poplar-type propolis, with reproducible chemical composition and anti-microbial activity, independently from the chemical composition of the starting raw propolis. Three raw propolis samples, from Europe, America, and Asia, were analyzed for their polyphenol chemical composition by means of HPLC-UV and then combined to obtain three mixtures of propolis, which werme submitted to the M.E.D. extraction method. The chemical composition and the antimicrobial activity of M.E.D. propolis against bacteria and fungi were determined. The three M.E.D. propolis showed similar chemical compositions and antimicrobial activities, exhibiting no relevant differences against antibiotic-susceptible and antibiotic-resistant strains. The batch-to-batch reproducibility of propolis extracts obtained with the M.E.D. method encourages the design of drugs alternative to traditional antibiotics and the development of anti-infective surface-modified biomaterials.
DOI: 10.3390/ma12223746
PubMed: 31766311
PubMed Central: PMC6888584
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Montesano 49, 80131 Napoli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmacy, Nutraceutical Lab, University of the Naples, Federico II, Via D. Montesano 49, 80131 Napoli</wicri:regionArea><wicri:noRegion>80131 Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Di Giovanni, Carmen" sort="Di Giovanni, Carmen" uniqKey="Di Giovanni C" first="Carmen" last="Di Giovanni">Carmen Di Giovanni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, Nutraceutical Lab, University of the Naples, Federico II, Via D. Montesano 49, 80131 Napoli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmacy, Nutraceutical Lab, University of the Naples, Federico II, Via D. Montesano 49, 80131 Napoli</wicri:regionArea><wicri:noRegion>80131 Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Galeotti, Fabio" sort="Galeotti, Fabio" uniqKey="Galeotti F" first="Fabio" last="Galeotti">Fabio Galeotti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 213/D, 41121 Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 213/D, 41121 Modena</wicri:regionArea><wicri:noRegion>41121 Modena</wicri:noRegion></affiliation></author><author><name sortKey="Gisone, Lucia" sort="Gisone, Lucia" uniqKey="Gisone L" first="Lucia" last="Gisone">Lucia Gisone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, 27100 Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Campoccia, Davide" sort="Campoccia, Davide" uniqKey="Campoccia D" first="Davide" last="Campoccia">Davide Campoccia</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna</wicri:regionArea><wicri:noRegion>40136 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Volpi, Nicola" sort="Volpi, Nicola" uniqKey="Volpi N" first="Nicola" last="Volpi">Nicola Volpi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 213/D, 41121 Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 213/D, 41121 Modena</wicri:regionArea><wicri:noRegion>41121 Modena</wicri:noRegion></affiliation></author><author><name sortKey="Arciola, Carla Renata" sort="Arciola, Carla Renata" uniqKey="Arciola C" first="Carla Renata" last="Arciola">Carla Renata Arciola</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna</wicri:regionArea><wicri:noRegion>40136 Bologna</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, via San Giacomo 14, 40126 Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, via San Giacomo 14, 40126 Bologna</wicri:regionArea><wicri:noRegion>40126 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Daglia, Maria" sort="Daglia, Maria" uniqKey="Daglia M" first="Maria" last="Daglia">Maria Daglia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, Nutraceutical Lab, University of the Naples, Federico II, Via D. Montesano 49, 80131 Napoli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmacy, Nutraceutical Lab, University of the Naples, Federico II, Via D. Montesano 49, 80131 Napoli</wicri:regionArea><wicri:noRegion>80131 Napoli</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013</wicri:regionArea><wicri:noRegion>Zhenjiang 212013</wicri:noRegion></affiliation></author></analytic><series><title level="j">Materials (Basel, Switzerland)</title><idno type="ISSN">1996-1944</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antimicrobial activity is a well-known property of propolis, making it a candidate for antimicrobial surfaces in biomedical devices. Nevertheless, large-scale use of propolis as an anti-infective agent is limited by the heterogeneity of its chemical composition and consequent variation in antimicrobial activity. The aim of this study was to demonstrate that the multi dynamic extraction (M.E.D.) method produces standardized polyphenolic mixtures from poplar-type propolis, with reproducible chemical composition and anti-microbial activity, independently from the chemical composition of the starting raw propolis. Three raw propolis samples, from Europe, America, and Asia, were analyzed for their polyphenol chemical composition by means of HPLC-UV and then combined to obtain three mixtures of propolis, which werme submitted to the M.E.D. extraction method. The chemical composition and the antimicrobial activity of M.E.D. propolis against bacteria and fungi were determined. The three M.E.D. propolis showed similar chemical compositions and antimicrobial activities, exhibiting no relevant differences against antibiotic-susceptible and antibiotic-resistant strains. The batch-to-batch reproducibility of propolis extracts obtained with the M.E.D. method encourages the design of drugs alternative to traditional antibiotics and the development of anti-infective surface-modified biomaterials.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31766311</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">1996-1944</ISSN><JournalIssue CitedMedium="Print"><Volume>12</Volume><Issue>22</Issue><PubDate><Year>2019</Year><Month>Nov</Month><Day>13</Day></PubDate></JournalIssue><Title>Materials (Basel, Switzerland)</Title><ISOAbbreviation>Materials (Basel)</ISOAbbreviation></Journal><ArticleTitle>Multi Dynamic Extraction: An Innovative Method to Obtain a Standardized Chemically and Biologically Reproducible Polyphenol Extract from Poplar-Type Propolis to Be Used for Its Anti-Infective Properties.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E3746</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/ma12223746</ELocationID><Abstract><AbstractText>Antimicrobial activity is a well-known property of propolis, making it a candidate for antimicrobial surfaces in biomedical devices. Nevertheless, large-scale use of propolis as an anti-infective agent is limited by the heterogeneity of its chemical composition and consequent variation in antimicrobial activity. The aim of this study was to demonstrate that the multi dynamic extraction (M.E.D.) method produces standardized polyphenolic mixtures from poplar-type propolis, with reproducible chemical composition and anti-microbial activity, independently from the chemical composition of the starting raw propolis. Three raw propolis samples, from Europe, America, and Asia, were analyzed for their polyphenol chemical composition by means of HPLC-UV and then combined to obtain three mixtures of propolis, which werme submitted to the M.E.D. extraction method. The chemical composition and the antimicrobial activity of M.E.D. propolis against bacteria and fungi were determined. The three M.E.D. propolis showed similar chemical compositions and antimicrobial activities, exhibiting no relevant differences against antibiotic-susceptible and antibiotic-resistant strains. The batch-to-batch reproducibility of propolis extracts obtained with the M.E.D. method encourages the design of drugs alternative to traditional antibiotics and the development of anti-infective surface-modified biomaterials.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zaccaria</LastName><ForeName>Vincenzo</ForeName><Initials>V</Initials><Identifier Source="ORCID">0000-0002-8143-2838</Identifier><AffiliationInfo><Affiliation>Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, 27100 Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garzarella</LastName><ForeName>Emanuele Ugo</ForeName><Initials>EU</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, Nutraceutical Lab, University of the Naples, Federico II, Via D. Montesano 49, 80131 Napoli, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Giovanni</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, Nutraceutical Lab, University of the Naples, Federico II, Via D. Montesano 49, 80131 Napoli, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galeotti</LastName><ForeName>Fabio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 213/D, 41121 Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gisone</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, 27100 Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campoccia</LastName><ForeName>Davide</ForeName><Initials>D</Initials><Identifier Source="ORCID">0000-0002-3336-0219</Identifier><AffiliationInfo><Affiliation>Laboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volpi</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 213/D, 41121 Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arciola</LastName><ForeName>Carla Renata</ForeName><Initials>CR</Initials><Identifier Source="ORCID">0000-0003-0382-0066</Identifier><AffiliationInfo><Affiliation>Laboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, via San Giacomo 14, 40126 Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daglia</LastName><ForeName>Maria</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-4870-7713</Identifier><AffiliationInfo><Affiliation>Department of Pharmacy, Nutraceutical Lab, University of the Naples, Federico II, Via D. Montesano 49, 80131 Napoli, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>Direzione Generale Istruzione, Formazione e Lavoro, Decreto dirigenziale n. 9752, published on 21st October 2014, grant number n. 1012</GrantID><Agency>Regione Lombardia</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>11</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Materials (Basel)</MedlineTA><NlmUniqueID>101555929</NlmUniqueID><ISSNLinking>1996-1944</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">anti-infective agent</Keyword><Keyword MajorTopicYN="N">anti-infective biomaterials</Keyword><Keyword MajorTopicYN="N">antibiotic-resistant bacteria</Keyword><Keyword MajorTopicYN="N">antimicrobial activity</Keyword><Keyword MajorTopicYN="N">multi dynamic extraction (M.E.D.) method</Keyword><Keyword MajorTopicYN="N">poplar-type propolis</Keyword><Keyword MajorTopicYN="N">standardized polyphenolic mixture</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>09</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>10</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>11</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>11</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Arciola</name><name sortKey="Campoccia, Davide" sort="Campoccia, Davide" uniqKey="Campoccia D" first="Davide" last="Campoccia">Davide Campoccia</name><name sortKey="Daglia, Maria" sort="Daglia, Maria" uniqKey="Daglia M" first="Maria" last="Daglia">Maria Daglia</name><name sortKey="Di Giovanni, Carmen" sort="Di Giovanni, Carmen" uniqKey="Di Giovanni C" first="Carmen" last="Di Giovanni">Carmen Di Giovanni</name><name sortKey="Galeotti, Fabio" sort="Galeotti, Fabio" uniqKey="Galeotti F" first="Fabio" last="Galeotti">Fabio Galeotti</name><name sortKey="Garzarella, Emanuele Ugo" sort="Garzarella, Emanuele Ugo" uniqKey="Garzarella E" first="Emanuele Ugo" last="Garzarella">Emanuele Ugo Garzarella</name><name sortKey="Gisone, Lucia" sort="Gisone, Lucia" uniqKey="Gisone L" first="Lucia" last="Gisone">Lucia Gisone</name><name sortKey="Volpi, Nicola" sort="Volpi, Nicola" uniqKey="Volpi N" first="Nicola" last="Volpi">Nicola Volpi</name></country><country name="République populaire de 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